|
KMID : 0360220210620040538
|
|
Journal of the Korean Ophthalmological Society
2021 Volume.62 No. 4 p.538 ~ p.544
|
|
|
Comparison of Optic Neuritis with Seropositive Myelin Oligodendrocyte Glycoprotein Antibody and Seropositive Neuromyelitis Optica Antibody
|
|
Kang Min-Chae
Park Kyung-Ah
|
|
|
Abstract
|
|
|
Purpose: To compare clinical outcomes of Korean patients with seropositive myelin oligodendrocyte glycoprotein antibody(MOG-IgG)-related optic neuritis (ON) and those with neuromyelitis optica antibody (NMO-IgG)-related ON.
Methods: Medical records were analyzed retrospectively among patients diagnosed with ON from January 2018 to June 2020,who were positive for MOG-IgG or NMO-IgG on serological tests. Clinical manifestations and outcomes were collected and comparedbetween the two groups.
Results: The study included 14 eyes of 10 MOG-IgG positive patients, and 38 eyes of 25 NMO-IgG positive patients. Final visualacuity differed significantly between the two groups (p = 0.002), and the proportion of patients with no light perception was higherin the NMO-ON group (11%) compared with the MOG-ON group (0%). The mean deviation value on visual field tests alsoshowed a significant difference between NMO-ON and MOG-ON groups (-18.98 ± 12.36 dB versus -10.17 ± 10.03 dB, respectively;p = 0.018). The recurrence rate was 42% in the NMO-ON group and 79% in the MOG-ON group (p = 0.020).
Conclusions: The clinical outcomes of NMO-ON and MOG-ON patients differed significantly. MOG-ON patients were more likelyto experience a relapse. Patients with NMO-ON were given a poor visual prognosis despite having a lower recurrence rate thanthose with MOG-ON.
|
|
|
KEYWORD
|
|
|
AQP-4 antibody, Myelin oligodendrocyte glycoprotein antibody, Neuromyelitis optica antibody, Optic neuritis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|